For more than 50 years, Los Robles Health System has led the way in providing a full range of diagnostic and treatment options for all areas of cardiovascular and neurovascular care, leading to the best outcomes for our patients. Our outcomes for heart and neurovascular care are consistently in the nation’s top 10 percent and we participate in multiple cutting-edge clinical trials.

Our multi-disciplinary cardiovascular team focuses on heart and vascular health, from diagnosis of heart disease to management of heart failure and everything in between.

Our dedicated multidisciplinary team of neurovascular professionals utilize state-of-the-art technology and clinical practices in neuroimaging, endovascular device development and advanced techniques in image guided minimally invasive surgery.

Our first and most important responsibility is to our patients and their families, ensuring they receive the best healthcare possible.

Heart clinical trials

The Cardiovascular Institute of Los Robles Health System conducts research for a wide range of cardiovascular disorders and offers patients opportunities to participate in research and clinical trials. Below is more information about clinical trials currently underway at Los Robles.

  • CLASP IID + IIF: Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip™ in patients with mitral regurgitation.

  • Boston Scientific OPTION: Comparison of Anticoagulation with Left Atrial Appendage Closure after AF Ablation

  • Abbott Repair MR: Percutaneous MitraClip Device or Surgical Mitral Valve REpair in PAtients with PrImaRy MItral Regurgitation who are Candidates for Surgery (REPAIR-MR)

  • Abbott TRILUMINATE Pivotal: Evaluate the safety and effectiveness of the TriClip™ device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation who have been determined by the site’s local heart team to be at intermediate or greater estimated risk for mortality with tricuspid valve surgery.

  • Bioventrix ALIVE: Clinical Study of the BioVentrix Revivent TC System for Treatment of Left Ventricular Aneurysms

  • Boston Scientific Protected TAVR: Stroke PROTECTion with SEntinel During Transcatheter Aortic Valve Replacement

  • Abbott MitraClip Expand G4: MitraClip G4 System Evaluate the safety and performance of the MitraClip™ G4 System in a post-market setting.

  • Highlife Medical HL-2019-01: An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

  • Abbott SUMMITT: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

  • RELIEVE-HF TRIAL: Provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System to reduce lung congestion symptoms and improve clinical outcomes in a certain high-risk subset of symptomatic patients suffering from heart failure.

  • Abbott Portico NG: Evaluation of the Portico NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis

  • Halfmoon Medical: Evaluation of the Safety and Performance of the Half Moon Transcatheter Mitral Valve Repair System in High Risk Patients with Severe, Symptomatic Mitral Regurgitation - The Half Moon TMVr Pilot Study

  • Abbott AMPLATZER PFO Occluder Post Approval Study

Contact us

Contact us to learn more about these and upcoming clinical trials at Los Robles Health System.

Mane Arabyan — Cardiovascular Research Coordinator
HCA Research Institute at Los Robles Health System
227 West Janss Rd., Suite 340
Phone: (805) 796-3746
Email: Email Mane

Cherry Papanicolao RN – Cardiovascular Research Coordinator
HCA Research Institute at Los Robles Health System
227 West Janss Rd., Suite 340
Thousand Oaks, CA 91360
Phone: (805) 368-1803
Email: Email Cherry

Neurovascular clinical trials

In close collaboration with HCA Research Institute, Los Robles Health System is engaged in several cutting-edge trials, with many more in the pipeline:

  • The APPLY Study: A Prospective, Single-Center Study Appraising the Embolization of Aneurysms using the Balt Optima Coil System

    • Sponsor: Vascular Neurology of Southern California, Inc.

    • The APPLY Study is an investigator-initiated prospective, real-world, single-center, post-market study conducted in Thousand Oaks, California. The purpose of this study is to demonstrate the efficacy and safety of the Balt Optima™ Coil System in the treatment of intracranial aneurysms.

  • ASSIST Registry

    • Sponsor: Stryker Neurovascular

    • The ASSIST Registry is prospective, global, consecutive enrollment Registry, which aims to determine the success of procedural and clinical outcomes associated with various mechanical thrombectomy techniques using Stryker Neurovascular devices in treatment of large vessel occlusions found in the anterior circulation.

  • EXCELLENT Registry: Embotrap eXtraction & Clot EvaLuation & Lesion Evaluation for NeuroThrombectomy

    • Sponsor: Cerenovus

    • The EXCELLENT Registry is a prospective, single-arm, real-world, multi-center study with sites located globally which aims to assess the efficacy of the EmboTrap Revascularization Device.

  • TESLA Trial

    • Sponsor: Investigator-Initiated Study funded by Genentech, Cerenovus, Medtronic, Penumbra, Stryker

    • The TESLA Trial is a prospective, randomized, open-label, blinded endpoint study that aims to determine the efficacy of intra-arterial mechanical thrombectomy in the treatment of acute ischemic stroke due to a large vessel occlusion in the anterior circulation that are currently not candidates for thrombectomy.

  • STEM Trial: The SQUID Trial for the Embolization of the Middle Meningeal Artery (STEM) For Treatment of Chronic Subdural Hematoma

    • Sponsor: Balt USA, LLC

    • The STEM Trial is a prospective, international, multi-center, randomized study established in effort to provide assessment of the safety and effectiveness of Middle Meningeal Artery (MMA) embolization of Chronic Subdural Hematoma.

  • SUCCESS Study: Success in Comaneci-assist Coils Embolization Surveillance Study

    • Sponsor: Rapid Medical

    • SUCCESS is a multi-center, single arm, prospective, post-market surveillance study aimed to assess safety and performance of the Comaneci Embolization Assist Device as it is indicated for use as a temporary endovascular device used to assist in the coil embolization of wide-necked intracranial aneurysms.